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   Clinical OverviewEpidemiologyThe RLS Epidemiology, Symptoms, and Treatment (REST) study, a prospective observational study of RLS prevalence, is the largest epidemiological survey conducted for RLS to date. In the primary care portion of the REST study, 23,052 patients visiting primary care physicians located in France, Germany, Spain, UK, and USA were given an RLS screening questionnaire. In the primary care group that completed questionnaires, 2223 (9.6%) reported RLS symptoms at least once a week.1 In the REST general population portion of the study, 16,202 randomly selected individuals from France, Germany, Spain, Italy, UK, and USA filled out RLS questionnaires. In the general population group that completed questionnaires, 2.7% (416) experienced RLS symptoms at least twice a week.2 The Memory and Morbidity in Augsburg Elderly (MEMO) study reports that RLS affects women twice as often as men.8 Other statistically significant epidemiological correlates of RLS include increased age, increased body mass index, lower socioeconomic status, diabetes, lack of exercise, and cigarette smoking.9 |